LDL-C对首次急性心肌梗死后左室收缩功能的预测价值

Prognostic value of LDL-C on left ventricular ejection fraction in patients with acute myocardial infarction

目的 探讨低密度脂蛋白胆固醇 (LDL C)对首次急性心肌梗死后左室收缩功能的预测价值。方法 对 40例首次急性心肌梗死行静脉溶栓治疗的患者 ,静脉采血化验心肌酶 (CPK MB) ,血脂及其他生化指标。Doppler超声测左室功能 (EF值 )。按低密度脂蛋白胆固醇 (LDL C)的水平分为正常LDL C组及高LDL C进行比较。结果 正常组左室射血分数 (LVEF)为 0 .6 4± 0 .0 6 5明显高于高LDL C组 0 .5 5± 0 .0 47(P <0 .0 1)。血清肌酸磷酸激酶同工酶峰值为 (143 .2 3± 81.48)U/L明显低于高LDL C组 (195 .82± 77.39)U/L(P <0 .0 5 )。总胆固醇 (TC)、甘油三酯 (TG)、LDL C以及CPK MBmax与LVEF间呈负相关 ,尤其是LDL C与LVEF间呈显著负相关。结论 低密度脂蛋白胆固醇对首次急性心肌梗死后左室收缩功能有较高的预测价值。

WT5”BX] Objective To study the prognostic value of low density lipoprotein cholesterol(LDL C) on left ventricular systolic function in patients with first acute myocardial infarction. Methods Forty patients with first acute myocardial infarction who underwent thrombosis therapy were studied. Blood samples were taken to measure lipids,CPK MB. Left ventricular ejection fraction(LVEF)was measured with Doppler echocardiography. All patients were divided into two groups according to their serum LDL C levels (group 1,LDL C<3.64 mmol/L; group 2,LDL C≥3.64 mmol/L). Results The postinfarction LVEF in group 1 (0.64±0 065)was higher than in group 2 (0.55±0.047)( P <0.01).CPK MBmax in group 1(143.23±45)U/L was lower than group 2(195.8±77.39)U/L( P <0.05).There was significant difference between two groups was found.A negative correlation was found between postinfarction LVEF and serum lipid profiles,especially between LVEF and LDL C( r =-0.513 1, P =0.000 7). Conclusion LDL C has significant predictive value for postinfarction LVEF. [WT5”HZ]