摘要
目的观察由埃索美拉唑、左氧氟沙星、阿莫西林、克拉霉素组成的10日序贯疗法对幽门螺杆菌阳性十二指肠球部溃疡的疗效及安全性。方法将经胃镜检查确诊十二指肠球部溃疡且幽门螺杆菌阳性的患者100例随机分为两组,治疗组(50例):为前5d给予埃索美拉唑+阿莫西林+克拉霉素三联治疗,后5d给予埃索美拉唑+左氧氟沙星+阿莫西林三联治疗;对照组(50例):为埃索美拉唑+阿莫西林+克拉霉素三联治疗,疗程均为10d,比较治疗后两组患者幽门螺杆菌根除率。结果治疗组幽门螺杆菌根除率94.00%,对照组为76.00%,其根除率两组差异有显著性(P<0.05),内镜下改变,序贯治疗组有效率98.00%(49/50),对照组有效率94.00%(47/50),两组比较差异无显著性(P>0.05)。结论以埃索美拉唑、左氧氟沙星等组成的10日序贯疗法对幽门螺杆菌感染的十二指肠球部溃疡具有较高的疗效及安全性。
【Objective】To evaluate the eradication rate and safety of ten days sequential therapy for helicobacter pylori (Hp) infection with esomeprazole, amoxicillin, levofloxacin and clarithromycin. 【Methods】100Hp-infected patients with duodenal ulcer were enrolled, these patients were randomly divided into treatment group (n=50) and control group (n=50). Patients in treatment group received esomeprazole, amoxicillin, for the first 5 days, and followed by esomeprazole, levofloxacin and amoxicillin for the last 5 days, and patients in control group received esomeprazole, clarithromycin and amoxicillin for 10 days. The status of Hp and endoscopic healing in patients of two groups were compared after completion of treatment. 【Results】 The eradication rate of sequential therapy was 94.00% and that of control group was 76.00%. There was significant difference between these two groups (P <0.05). The endoscopic healing rate of sequential therapy was 98.00% and that of control group was 94.00%. There was no significant difference between these two groups (P >0.05). 【Conclusion】 The 10 -day sequential therapy can achieve higher eradication rate of Hp, endoscopic healing rate and safety.
出处
《中国内镜杂志》
CSCD
北大核心
2012年第12期1304-1306,共3页
China Journal of Endoscopy