支气管结核初治涂阳患者介入加口服药物与单纯口服药物治疗的对比研究

Comparative study of intervention treatment plus drugs and drug treatment for new smear positive bronchial tuberculosis patients

目的探讨经纤维支气管镜介入治疗初治涂片阳性(简称"涂阳")支气管内膜结核联合口服抗结核药物治疗的效果。方法将我科2010年2月至2011年8月收治的初治痰涂片阳性支气管内膜结核患者80例,按照完全随机(队列法)分为两组,纤维支气管镜介入加口服抗结核药物治疗为介入组,共40例,平均年龄(35.6±8.5)岁,其中男11例,女29例;单纯口服抗结核药物治疗为对照组,共40例,平均年龄(35.2±6.8)岁,其中男17例,女23例,两组患者在性别(χ2=1.978,P=0.241)和年龄(t=0.218,P=0.828)上差异无统计学意义,具有可比性。相关治疗方案均告知患者并已签署知情同意书。数据录入采用Excel软件,介入组与对照组治疗总有效率的比较采用SPSS 13.0统计分析软件包行χ2检验,P<0.05为差异有统计学意义。结果两组患者经过治疗后,介入组40例中,显效和有效37例,无效3例,总有效率为92.5%(37/40)。对照组40例中,显效和有效28例,无效12例,总有效率为70.0%(28/40),两组比较差异有统计学意义(χ2=6.646,P<0.05)。结论经纤维支气管镜介入注药加口服抗结核药物治疗,疗效优于单纯口服抗结核药物治疗。

Objective To explore the treatment effect of new smear positive endobronchial tuberculosis cases by fiberoptic bronchoscopic interventional therapy combined with oral anti-TB drugs. Methods 80 new smear positive endobronchial tuberculosis cases admitted to the Department of Respiratory Medicine from February 2010 to August 2011 was divided randomly （queue law） into two groups, the intervention group received fiberoptic broncho- scopic interventional therapy and oral anti-TB drugs, while the control group received oral anti-TB drugs. There were 40 cases in each group, with 11 male and 29 female in intervention group and 17 male and 23 female in control group. The average age of the intervention group was （35.6±8. 5）, while that of the control group was （35.2±6.8）. The sex （%2 =1. 978, P=0. 241） and age （t=0. 218, P=0. 828） of the two groups were comparable with each other. Related treatment prescriptions were informed before signed informed consent provided. Excel software was used for data entry. SPSS 13.0 was used for analysis. P〈0.05 was defined as the criteria for statistically significant difference. Results After treatment, 37 cases acquired remarkable effect or normal effect in the intervention group, and the total effective rate was 92.5%（37/40）. While in the control group, 28 cases acquired remarkable effect or normal effect with 70.0% （28/40） total effective rate. Conclusion The effect of fiberoptic bronchoscopic interventional therapy combined with oral anti-TB drug therapy was better than that of oral anti-TB drugs.