乳源性活性肽在仔猪胃肠道适应性变化中的作用

Role of Milk-Borne Growth Factors in Postnatal Adaptation of the Gastrointestinal Tract in Neonatal Pigs

仔猪出生以后 ,尤其是在出生与断奶时 ,其胃肠道面临着众多挑战与应激性变化。为了适应这些挑战 ,消化道发生了明显的变化 ,包括出生后消化道组织的快速生长与成熟以及断奶后小肠绒毛萎缩 ,隐窝深度增加。这些变化明显与出生后食入初乳以及断奶后停止供乳有关。猪乳不仅营养丰富 ,而且含有众多生物活性物质 ,包括各种生长因子 ,如 EGF、IGF- 、IGF- 、胰岛素与 TGF-β等。许多试验资料显示 。

After brith,particularly at the time of birth and weaning,the gastrointestinal (GI) tract of the neonatal pig encounters numerous challenges and severe stress.To adapt to the challenges the GI tract undergoes marked changes,including accelerated tissue growth and functional maturation during the immediate postnatal period and intestinal villous atrophy and damage following weaning.The changes are apparently related to the onset of colostrum ingestion at the time of birth and the withdrawal of mile ingestion at the time of weaning.Porcine colostrum and milk contain not only highly digestible nutrients but also numerous bioactive compounds,including various types of growth factors,including EGF,IGF Ⅰ,IGF Ⅱ,insulin and TGF β.Much experimental evidence indicates a regulatory role of these milk borne growth factors in simulating GI tissue growth and function maturation and enhancing repair of damaged GI mucosa in the suckling young.