幽门螺杆菌感染与C反应蛋白水平的相关性研究

Clinical significance of C-reactive protein in Helicobacter pylori associated gastric diseases

目的:幽门螺杆菌感染可能引起全身炎症反应,本研究旨在探讨慢性胃炎、胃溃疡、胃癌患者中HP感染与血清C反应蛋白(CRP)水平的相关性。方法:选取行胃镜检查及碳-14呼气试验检查的慢性胃炎患者70例,胃溃疡患者64例,胃癌患者62例,并行血清CRP水平检测。结果:慢性胃炎HP阳性组的CRP水平为(11.28±2.12)mg/L,阴性组为(8.09±1.26)mg/L,两者比较差异有统计学意义(P<0.05)。胃溃疡组HP阳性组的CRP水平为(16.32±3.62)mg/L,阴性组为(13.21±2.08)mg/L,两者比较差异有统计学意义(P<0.01)。恶性胃溃疡HP阳性组的CRP水平为(20.65±6.58)mg/L,阴性组为(16.12±5.86)mg/L,两者比较差异有统计学意义(P<0.05)。胃溃疡组血清CRP浓度高于慢性胃炎组,差异有统计学意义(P<0.05),胃癌组血清CRP水平高于慢性胃炎及胃溃疡组,差异有统计学意义(P<0.05)。结论:血清CRP水平在幽门螺杆菌感染的患者中增高,表明HP感染可以影响血清CRP水平,同时CRP可以作为判断HP相关性胃疾病患者病情严重程度指标之一。

Objective： Helicobacter pylori （HP） infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the HP infection and serum C-reactive protein （CRP） levels in chronic gastritis ,gastric ulcer and gastric cancer patients.Methods：Subjects were comprised of 70 cases of chronic gastritis,64 cases of gastric ulcer and 62 cases of gastric cancer.electronic gastroscopy, 14C-urea breath test and serum concentrations of CRP testing were carried out at the the time of diagnosis.Results：Mean serum CRP level of gastric ulcer group was higher than that of chronic gastritis group and the difference was significant;mean serum CRP level of gastric cancer group was higher than that of gastric ulcer group and chronic gastritis group, the difference was significant.Mean serum CRP concentration of the HP positives was higher than HP positives,and the difference was significant.Conclusions： CRP was higher among the HP infected individuals,indicated HP infection could influence the CRP levels.at the same time,CRP levels also related to the severity of HP-related patients with gastric diseases.