川芎汤与冠心Ⅱ号吸收入人血清中阿魏酸的血药浓度-时间曲线

Comparison of ferulic acid concentration-time profiles absorbed into serum between oral ligusticum wallichi and coronary heart NoⅡdecoctions

目的 :探讨方剂配伍对吸收入体内血药浓度及其药物动力学参数的影响。方法 :用已建立的 HPL C法 [1 ] ,测定健康自愿者一次口服川芎汤 (1g· kg- 1 )、冠心 号汤 (6 g/kg,其中川芎为 1g/kg)后血清中阿魏酸 (FA)的血药浓度 -时间曲线。结果 :均表现为双峰现象 ;川芎汤和冠心 号在健康人血清中 FA的血药浓度时间曲线下面积(AU C)分别为 15 735± 70 6 4和 15 886± 80 6 2 μg· L- 1· m in- 1 ;健康人血清中川芎复方来源的 FA血药浓度最高和最低定量值之间表现出 3～ 8倍的差异。结论 :在冠心 号中川芎配伍芍药、红花和丹参等并不影响体内 FA的血药浓度及其生物利用度。

AIM: To explore the effect of composition of prescription on blood drug concentration in vivo and its pharmacokinetics. METHODS: Serum ferulic acid (FA) concentration time profiles were determined and compared by our previously published method after oral administrations of ligusticum wallichi(1 g/kg) and coronary heart NoⅡdecoctions(6 g/kg)to healthy volunteers. RESULTS: There were the two peak phenomenon of serum FA concentration time curve which was the open one compartment models. the Area under concentration (AUC) of FA in serum of ligusticum wallichi and coronary heart NoⅡ decoctions in volunteers was 15735±7064 and 15886±8062 μg·L -1 ·min respectively. there were 3~8 times difference between maximum and minimum quantitative value of serum FA concentration. CONCLUSION: In coronary heart NoⅡ decoctions, that ligusticum wallichi add white peony root, safflower and root of red sage don′t affect the blood drug concentration and AUC of FA.