冠状动脉内支架安置术后纤溶及前列腺素水平的变化及其临床意义

The clinical significance of the change in fibrinolytic activity and prostaglandin level with introcoronary stent

目的 :观察冠心病患者冠状动脉内支架 (ICS)安置术后外周血中纤溶和前列腺素水平的变化及其临床意义。方法 :将 2 4例患者分为肝素涂层支架组 (n=9)和普通支架组 (n=15 ) ,测定 ICS术前、术后 2 ,2 4h,7d血浆血栓素B2 (TXB2 )、6 -酮 -前列腺素 F1α(PGF1α)、组织型纤溶酶原激活物 (t- PA)及其抑制物 (PAI- 1)的变化。结果 :肝素支架组与普通支架组术后 T X B2 ,PGF1α明显升高 ,术后 2 4h达高峰 ;t- PA与 PAI- 1术后无明显变化。结论 :ICS术后确有血小板活化 ,纤溶活性变化不大。肝素支架组与普通支架组并无显著差别。

AIM: To study the active changes of the fibrinolysis and the prostaglandin undergoing introcoronary stent (ICS)in the patients with coronary heart disease in order to guide the clinical drug usage. METHODS: The patients were divided into heparin coated stent (n=9)and non coated stent (n=15) groups and we determined the concentrations of thromboxane B 2(TXB 2), 6 Keto prostaglandin F 1α (6 Keto PGF 1α ), tissue type plasminogen activator (tPA)and plasminogen activator inhibitor 1(PAI 1)in 2,24 hours and 7 days after ICS. RESULTS: Both of the TXB 2 and 6 Keto PGF 1α were higher after ICS than before, rising to the peak at 24, but tPA and PAI 1 had no significant changes. CONCLUSION: Platelet may be activated after ICS and the fibrinolysis were the same as before. There are no significant differences between the heparin coated stent and non coated stent groups.