北京市石景山区1985—2008年新涂阳肺结核非住院患者4种化疗方案疗效回顾性分析

Retrospective analysis of the therapeutic efficacy of four chemotherapy regimens for newly diagnosed smear-positive outpatients with pulmonary tuberculosis in Shijingshan District of Beijing during 1985-2008

目的评价北京市石景山区1985—2008年新涂阳肺结核病例非住院全面督导化疗效果。方法石景山区1985—2008年管理的1133例新涂阳肺结核患者在不同时期分别采用了12个月疗程的标准化疗方案、2种6个月疗程的短程化疗间歇方案和6个月疗程的短程化疗每日方案4种治疗方案。通过收集这1133例新涂阳肺结核患者资料,对不同治疗方案组的治疗成功率、3年复发率和不良反应发生率等资料进行比较分析。结果治疗成功率方面,短程化疗每日方案最高(97.2%),标准化疗方案最低(84.3%);短程化疗每日方案和短程化疗间歇方案1的3年复发率和不良反应发生率最低。结论综合考虑4组方案的治疗成功率、3年复发率和不良反应发生率,短程化疗每日方案优于2种短程化疗间歇方案和标准化疗方案。

Objective To evaluate the effect of directly observed chemotherapy on newly diagnosed smear-positive outpatients with pulmonary tuberculosis （TB） in Shijingshan District, Beijing, during 1985-2008. Methods Totally 1133 newly diagnosed smear- positive pulmonary TB outpatients in Shijingshan District during 1985-2008 were given 4 chemotherapy regimens, one-year course of standard chemotherapy regimen, short-course （half a year） intermittent chemotherapy regimen 1, short-course （half a year） intermit- tent chemotherapy regimen 2 and short-course daily chemotherapy regimen. The treatment success rates, incidence of adverse reac- tions and the three-year recurrence rates of the different treatment groups were compared and analyzed. Results The treatment suc- cess rate was the highest in short-course daily chemotherapy regimen group （97.2%） and the lowest in standard chemotherapy regimen group （84.3%）. The three-year recurrence rates and adverse reaction rates were the lowest in short-course daily chemotherapy regi- men group and short-course intermittent chemotherapy regimen 1 group. Conclusion To take the treatment success rates, three-year recurrence rates and adverse reaction rates into account, shortcourse daily chemotherapy regimen is superior to short-course intermit- tent chemotherapy regimens and standard chemotherapy regimen.