127例系统性红斑狼疮患者超声心动图特点的临床研究

A Clinical Study of Echocardiographic Characteristics of Cardiac Abnormalities in 127 Cases of Systemic Lupus Erythematosus

目的:探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)患者的超声心动图特点。方法:回顾性分析2004年1月至2011年6月确诊的127例SLE患者的超声心动图检查资料。结果:114例(89.76%)SLE患者存在心脏损害,其中瓣膜反流发生率最高,占76.38%(97/127),以二尖瓣、三尖瓣反流最为常见;其次为心脏结构改变24.41%(31/127)和心包积液23.62%(30/127)。重度活动SLE患者的左室射血分数减低的发生率明显高于轻中度活动的SLE患者(χ2=6.00,P<0.05),病程≥5年的SLE患者肺动脉高压的发生率明显高于病程<5年的SLE患者(χ2=4.68,P<0.05)。结论:系统性红斑狼疮患者心脏改变发生率高,且随着病情变化,超声心动图显示瓣膜功能也呈现易变性,早诊断和合理治疗可逆转早期心血管改变。

Objective： To investigate the echocardiographic characteristics of patients with sys- temic lupus erythematosus. Methods： Echocardiographic data of 127 in-patients diagnosed with SLE from January 2004 to June 2011 were retrospectively analyzed. Results： 114 cases（89. 76% ） with SLE had cardiac abnormalities, including 97 cases （76.38%） with valvular regurgitation, 31 cases （24. 41% ） with structural changes of heart, and 30 cases （23.62%） with pericardial effu- sion. The percentage of reduced ejection fraction of left ventrieular in severe group was significant- ly larger than that in mild to moderate group, divided by disease activity （X2 = 6. 00, P 〈 0. 05 ）. The percentage of pulmonary artery hypertension in the group of disease duration of five years or longer was significantly larger than that in shorter duration group （ X2 = 4.68, P 〈 0. 05 ）. Con- clusion：Incidence of cardiac abnormality in patients with SLE is high. Valvular function varies as the disease progress. Early diagnosis and treatment can reverse early cardiovascular abnormalities.