2型糖尿病合并血管闭塞性病变的相关因素分析

Clinical Study of the Risk Factors in Type-2 Diabetes Patients with Vascular Occlusive Disease

目的探讨2型糖尿病合并血管闭塞性病变的危险因素。方法将213例2型糖尿病患者分为糖尿病合并血管闭塞性病变(DA)组和非合并血管闭塞性病变(NDA)组,比较两组之间的性别、年龄、病程、吸烟史、体重指数(BMI)、血糖(PG)、血脂、胰岛素(Ins)、C肽(CP)、血尿酸(UA)、胰岛素抵抗指数等指标,并采用Logistic回归分析2型糖尿病患者合并血管闭塞性病变组的相关危险因素。结果 DA组患者年龄、糖尿病病程、吸烟史、颈围、腰围、臀围、BMI、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、糖化血红蛋白(HbA1C)、尿酸(UA)、血糖、胰岛素、C肽、胰岛素抵抗指数(HOMA-IR)较NDA组明显升高(P<0.05),Logistic回归分析显示,2型糖尿病合并血管闭塞性病变的独立危险因素分别为HOMA-IR、吸烟、TC、病程、HbA1C、BMI和UA。结论胰岛素抵抗、吸烟、高胆固醇、病程、高HbA1C、肥胖和高尿酸血症是2型糖尿病合并血管闭塞性病变的危险因素。

Objective To analyze the risk factors in type-2 diabetes mellitus （T2DM） patients with vascular occlusive disease. Methods 213 patients with type-2 diabetes were divided into vascular occlusive disease （DA） group and non- vascular occlusive disease （NDA） group. Gender, age, duration of diabetes, smoking history, body mass index （BMI）, plasma glucose （PG）, blood lipids, insulin （Ins）, C-peptide （CP）, uric acid （UA）, insulin resistance between the two groups were compared. Logistic regression analysis was used in this analysis. Results The duration of diabetes, smoking history, neck circumference, waist circumference, hip circumference, BMI, triglyceride （TG）, total cholesterol （TC）, low density lipoprotein （LDL）, glyeosylated hemoglobin （HbA1C）, uric acid, blood glucose, insulin, C-peptide, and insulin resistance index （HOMA-IR） in the DA group were higher than the NDA group （P〈0.05）. Logistic regression analysis showed that HOMA-IR, smoking, TC, disease duration, HbA1C, BMI, and UA were the independent risk factor for avascular occlusive disease. Conclusion Insulin resistance, smoking, high cholesterol, duration, high level of HbA1C, obesity and hyperuricemia are the risk factors for type-2 diabetic patients with macrovascular disease.