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乌司他丁对支气管哮喘小鼠氧化应激及血红素加氧酶-1的影响 被引量：5

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摘要 乌司他丁（Ulinastatin）是一种高效广谱水解酶抑制剂，临床上已广泛应用于弥漫性血管内凝血、急性肺损伤等炎性疾病的治疗，但其在过敏性哮喘中的抗氧化作用及其与血红素加氧酶-1（heme oxygenase-1，HO-1）的关系尚不明了，本研究中从氧化应激角度探讨乌司他丁在卵清白蛋白（OVA）诱导的支气管哮喘（简称哮喘）小鼠模型中的作用及其与HO-1的关系，为探寻新的高效安全的临床哮喘治疗药物提供线索。
作者 宋冬梅 刘刚 牛英豪 王建涛 薛静 吕欣 杨建旺 王宝山
机构地区 河北医科大学第一医院耳鼻咽喉及变态反应科 重庆医科大学附属大学城医院急诊科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2013年第3期225-226,共2页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 河北省自然科学基金（H2012206004）
关键词 血红素加氧酶-1 支气管哮喘 乌司他丁 氧化应激 哮喘小鼠 广谱水解酶抑制剂 弥漫性血管内凝血 哮喘治疗药物
分类号 R5 [医药卫生—内科学]
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参考文献9

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二级参考文献17

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共引文献64

同被引文献31

  • 1沈华浩,王苹莉.支气管哮喘小鼠模型应用评价[J].中华结核和呼吸杂志,2005,28(4):284-286. 被引量：65
  • 2Hayashi S,Omata Y,Sakamoto H,et al. Character ization of rat heme oxygenase-3 gene. Implication of processed psendogenes derived from heine oxygenase-2 gene [J]. Gene,2004,336(2):241-250.
  • 3Effros RM, Nagaraj H. Asthma:new developments concerning immune mechanisms, diagnosis and treatment[J]. Cur Opin Pulmonary Med, 2007, 13 (1) :37-43.
  • 4Overhaus M, Moore BA, Barbato JE, et al. Biliverdin protects against polymicrobial sepsis hy modulating inflammatory mediators[J].Am J Physiol Gastroi- ntest Liver Physiol, 2006,290 (4) : 695-703.
  • 5Hegazi RA,Rao KN, Mayle A,et al. Carbon monoxide ameliorates chronic routine colitis through a heme oxygenase I-dependent pathway [J].J Exp Med,2005,202(12) : 1703-1713.
  • 6Xia ZW,Zhong WW,Xu LQ,et al. Heine oxygenase- 1-mediated CD4 CD25 regulatory T cells suppress allergie airway inflammation[J]. J Immunol, 2006, 177(9) : 5936-5945.
  • 7Kobayashi H, Takeno M, Saito T, et al. Regulatory role of heineoxygenase 1 in inflammation of rheuma- toid arthritis [J]. Arthritis Rheum, 2006, 54 (4) : 1132-1142.
  • 8Kobayashi H, Takeno M, Saito T, et al. Regulatory role of heme oxygenase 1 in inflammation of rheu- matoid arthritis[J]. Arthritis Rheum, 2006,54 (4): 1132-1142.
  • 9王珊琳.咪喹莫特对哮喘小鼠气道炎症和调节性T细胞的影响[J].中国临床药理学与治疗学,2011,16(1):33-37. 被引量：1
  • 10严跃红,黄爱群,李显波,荆小莉.乌司他丁对心肺复苏后兔肾损伤的影响[J].中国病理生理杂志,2011,27(6):1138-1142. 被引量：8

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中华结核和呼吸杂志
2013年 第3期

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