超声引导下多电极射频治疗原发性肝癌

Treatment of primary hepatic carcinoma by radio frequency thermal ablation under the guidance of ultrasonography

目的 探讨超声引导下多电极射频疗法对原发性肝癌的治疗效果。方法 在超声引导下 ,对 5 4例原发性肝癌患者行多电极射频治疗 ,观察治疗前后肿瘤声像图表现、大小、血流频谱、AFP水平及生存率变化。结果 多电极射频治疗后 ,肿瘤区由术前等或低或略高回声转变成强弱不等点状回声 ,术后 1～ 2周 46例病灶内动静脉血流频谱几乎消失。术后 2～ 6周 3 8例AFP阳性患者转阴 3 1例 ,下降 4例 ,有效率 92 .1%。术后 3个月复查超声或CT显示 47例 ( 87.0 % )患者肿瘤体积缩小 2 5 %以上。所有患者均得到随访 ,5 2例患者存活超过 3个月 ,最长已达 7个月。结论 多电极射频疗法是治疗原发性肝癌新的有效方法。

Objective To explore the effect of multi electrode radio frequency thermal ablation under the guidance of ultrasonography on primary hepatic carcinoma. Methods Fifty four cases of primary hepatic carcinoma were undergone multi electrode radio frequency thermal ablation under the guidance of ultrasonography. The imaging and size of tumor, intratumor blood flow, AFP level in serum,and survival rate were observed before and after the ablation.Results Tumor areas were turned into spotty uneven echo from equal,hyper or hypoechoic imaging in pretreatment.Doppler examination showed that intratumor blood flow almost disappeared 1～2 weeks after ablation in 46 cases. Blood AFP level in 31 out of 38 cases with AFP positive were turned negative and 4 cases showed declining tendency within 2～6 weeks,the effective rate of therapy was 92.1 %.CT or ultrasonography examination showed that the tumor size in 47 cases of 54 patients ( 87.0% ) decreased more than 25% in area 3 months after therapy .All of the patients were followed up, with 52 patients surviving more than 3 months, the longest 7 months.Conclusions Multi electrode radio frequency thermal ablation is a new effective way for the treatment of primary hepatic carcinoma.