摘要
目的探讨粘着斑激酶的基因多态性与冠心病的关系。方法目前已知的FAK两个cSNP位点分别是C2564T和G3104T,它们编码的蛋白质分别由Pro,Gly转变成Ser,Cys。本研究采用基因多态性检测方法(PCR+RFLP)检测冠脉造影确诊的冠心病患者215例(男109例,女106例)及与其年龄,性别及体重指数相匹配的健康体检者168例(男86例,女82例)FAK的一个cSNP位点C2564T的基因型,探讨FAK的C2564T基因型与冠心病的关系。结果男性冠心病患者中FAK的C2564T基因型等位基因T和C与男性健康体检者中等位基因T和C比较差异有统计学意义(P<0.05)。女性冠心病患者与女性健康体检者两组比较亦差异有统计学意义(P<0.05)。结论 FAK的C2564T基因型可能与冠心病的发生有一定的关系。
Objective To explore the relationship between signal nucleotide polymorphism of FAK and coronary heart disease. Methods 215 CHD（coronary heart disease）patients who underwent coronary angiography and168 healthy control subjects were recruited in this study.They were genotyped according to the technique of polymerase chain reactionrestriction fragment length polymorphism.The distribution of T genotype and C genotype in the two groups were compared. Results In the case group of male,there was significant difference in the distribution of T and C genotype between the case group and the control group （P 〈 0.05）.In the case group of female,there was significant difference in the distribution of T and C genotypes between the case group and the control group （P 〈 0.05）. Conclnsion There is association between T and C genotype of FAK C2564T and the happening of coronary heart disease.
出处
《中国医药科学》
2013年第5期22-23,85,共3页
China Medicine And Pharmacy
关键词
粘着斑激酶
基因多态性
冠状动脉疾病
Focal adhesion kinase
Signal nucleotide polymorphism
Coronary heart disease
