胱抑素C诊断早期糖尿病肾病的临床意义

Application value of serum cystatin C for diagnosing early diabetic nephropathy

目的探讨胱抑素C在糖尿病肾病早期诊断中的临床意义。方法根据不同尿蛋白排泄率将248例2型糖尿病患者分组,根据简化的MDRD方程估计肾小球滤过率。结果临床糖尿病肾病组BMI,WHR、SBP、DBP、尿酸等水平显著高于T2DM组,差异有统计学意义(P<0.05),临床糖尿病肾病组Cys-C水平明显高于T2DM组,差异有统计学意义(P<0.05)。结论胱抑素C为诊断早期糖尿病肾病的理想指标,对于早期诊断有重要意义。

Objective To study the application value of serum cystatinC for diagnosing early diabetic nephropathy. Methods 248 patients with type 2 diabetes were divided into three groups according to different urinary albumin excretion rate （UAER）,According to the simplified MDRD equ.ation to estimate glomerular filtration rate（eGFR）. Results Total DN group＇s BMI,WHR,SBP ,DBP,UA were higher than the T2DM group （P 〈 0.05）, The Cys-C were significantly higher in the diabetic nephropathy group,and as the illness progressed, the level of serum Cys-C increased gradually（P 〈 0.05）. Conclusion Serum Cys-C is a ideal marker to the early diagnosis of diabetic nephropathy.