妊娠期糖代谢异常孕妇外周血及脐血Ghrelin水平与母儿体质指标的相关性

Relationship between Maternal Periphery and Cord Blood Ghrelin Levels and Body Index in Gestational Abnormal Glucometabolism Patients

【目的】探讨妊娠期糖代谢异常孕妇外周血与脐血Ghrelin水平与母儿体质指标的关系。【方法】收集2009年11月至2010年2月于中山大学附属第一医院产科住院分娩的糖代谢异常孕妇32例,糖代谢正常孕妇24例。记录母亲体质量身高和新生儿出生体质量、身长及头围、胸围、大腿围值,以LANGE皮脂厚度测量仪测定新生儿肩胛下、大腿、髂上、肱三头肌及腹壁皮褶厚度;ELISA法测定分娩前母亲外周血及脐血Ghrelin水平,与上述体质指标进行分析。【结果】糖代谢异常组孕妇外周血Ghrelin水平(μg/L;9.4±4.0)较糖代谢正常组(12.0±3.9)显著降低(P<0.05)。母亲外周血Ghrelin水平与孕前体质量(r=-0.267,P<0.05)呈负相关趋势。两组中脐血Ghrelin水平与新生儿体质指标呈负相关趋势。【结论】脐血Ghrelin水平与新生儿体质指标呈负相关趋势。

[ Objectives ] To explore the maternal periphery and cord ghrelin level in abnormal glucometabolism mothers with good glucose control. Analyzing the clinical data and experimental markers, to find out what is correlated with neonatal body index, and to explore the relationship between ghrelin and fetal growth. [ Methods ] Totally 56 women who delivered in the First Affiliated Hospital of Sun Yat-sen University from November 2009 to February 2010 were enrolled. Totally 32 cases of abnormal glucometabolism with good glucose control and 24 cases of normal glucose tolerance. The clinical data was analyzed retrospectively. The neonatal anthropometry, including birth weight, neonatal body length, head circumference, chest circumference, upper arm circumference, thigh circumference, and abdominal circumference, were recorded. LANGE skinfold caliper was used to measure the neonatal subscapular skinfold thickness, thigh skinfold thickness, suprailiac skinfold thickness, triceps skinfold thickness and hypodermic fat thickness of abdomen within 24 hours after birth. ELISA was used to detect serum ghrelin level in maternal periphery and cord blood, then SPSS software was used to compare these markers. [ Results ] Maternal periphery ghrelin level of AGM group was lower than that of NGT group. Maternal periphery ghrelin level had negative trend with pregestational weight, pregestational BMI, antepartum weight, and antepartum BMI. [ Conclusions ]Matemal periphery ghrelin level of AGM group was lower than that of NGT group; Cord blood ghrelin level had negative trend with the birth weight, length, head circumference, skinfold thickness and complicated nutrition index both in AGM and NGT group.