2型糖尿病周围神经病变与C肽水平的相关性研究

Relationship between type 2 diabetic peripheral neuropathy and C-peptide level

目的了解住院2型糖尿病患者周围神经病变的患病率,探讨C肽与DPN的相关关系,研究DPN的危险因素。方法根据是否合并DPN将211例T2DM患者分为3组:单纯2型糖尿病组(T2DM组,n=44)与T2DM合并轻度周围神经病变组(轻度病变组,n=89),中、重度周围神经病变组(中重度病变组,n=78)。结果住院T2DM患者DPN的患病率为79.14%,总神经病变组(轻度+中重度病变组)年龄、病程、HbA1C、PBG、吸烟等水平显著高于T2DM组,差异有统计学意义(P<0.05)。空腹C肽、糖负荷2hC肽水平均显著低于T2DM组,差异有统计学意义(P<0.01)。DPN与年龄、病程、BMI、HbA1C成正相关(P<0.05),与2hC肽成负相关(P<0.05)。年龄、病程、吸烟、HbA1C是DPN的独立危险因素,2hC肽为保护因素。结论住院的T2DM患者DPN患病率较高,糖负荷2hC肽水平与T2DM发生DPN密切相关,C肽对周围神经具有保护作用。

Objective To understand the incidence of hospitalized patients with type 2 diabetic peripheral neuropathy, investigate the relationship between type 2 diabetic peripheral neuropathy and C-peptide level, and analyze the risk factors of I）PN. Methods The patients were divided into three groups： type 2 diabetes mellitus group （T2DM group, n=44 ）, type 2 diabetes mellitus and mild peripheral neuropathy group （mild group, n=89 ）, type 2 diabetes mellitus and severe peripheral neuropathy group （severe group,n=78 ）. Results The prevalence of DPN in hospitalized diabetic patients was 79.14% .Total peripheral neuropathy group＇s age, duration, HbA1C, PBG, smoking levels were higher than the T2DM group （P 〈 0.05 ）. Fasting C-peptide, glucose load 2 h C-peptide levels were significantly lower than the T2DM group （P 〈 0.01 ）.Age, duration, smoking, HbA1C were independently risk factors of peripheral neuropathy in type 2 diabetic patients, glucose load 2 h C- peptide was negatively correlated（P 〈 0.05 ）. Conclusion The prevalence of DPN in hospitalized diabetic patients is high. T2DM complicated by DPN is closely related to glucose load 2 h C-peptide level. C-peptide has a protective effect on peripheral nerve.