脂联素的生物学作用及临床应用

Biological functions and clinical implications of adiponectin

脂联素(adiponectin,APN)是一种脂肪细胞为主分泌的细胞因子,已证实其具有调节代谢、血管内皮保护、抗炎症反应及心肌细胞保护等多种生物学作用,并发现其也可作为潜在的心血管疾病的生物学标志物。本文根据基础医学、转化医学研究的结果及临床流行病学数据,综述了APN的生物学作用及其临床应用前景。

Adiponectin is one of the key adipokines. Identified biological functions of adiponectin include metabolic regulation, vascular protection, anti-inflammation and eardioproteetive actions. Numerous clinical studies have demonstrated that adiponeetin is one potential biological marker of cardiovascular diseases. In the present review, the biological functions and clinical prospect of adiponectin are discussed based on the findings of basic science and translational medicine along with clinical epidemiological data.