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RECK和基质金属蛋白酶与恶性肿瘤预后的研究进展 被引量：7

Correlation of RECK and matrix matalloproteinases with the prognosis of malignant tumor
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摘要 伴有kazal基序富含半胱氨酸的逆转诱导蛋白(reversion-inducing cysteine-rich protein with Kazal motif,RECK)基因是新近发现的基质金属蛋白酶(matrix matalloproteinase,MMP)抑制剂,能在转录后水平抑制多种MMP的表达而抑制肿瘤的侵袭及转移。RECK与乳腺癌、胰腺癌、骨肉瘤等疾病患者的预后存在正相关关系。文中综述RECK和MMP与各系统肿瘤的关系。 The reversion-inducing-cysteine-rich protein with Kazal motifs （RECK） gene, a newly found matrix matalloprotein- ase （MMP） inhibitor, can inhibit tumor invasion and metastasis by negatively regulating the expressions of various MMPs. RECK is positively correlated with the prognosis of breast cancer, pancreatic cancer and osteosarcoma.
作者 胡亚威 施鑫 吴苏稼 周光新
机构地区 南方医科大学南京临床医学院(南京军区南京总医院)骨科
出处 《医学研究生学报》 CAS 北大核心 2013年第3期330-333,共4页 Journal of Medical Postgraduates
关键词 回复引导半胱氨酸丰富蛋白含kazal基序 基质金属蛋白酶 恶性肿瘤 预后 Reversion-inducing cysteine-rich protein with Kazal motif Matrix matalloproteinase Malignant tumor Prognosis
分类号 R730.2 [医药卫生—肿瘤]
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参考文献18

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二级参考文献75

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共引文献31

同被引文献93

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引证文献7

二级引证文献33

医学研究生学报
2013年 第3期

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