视盘黑色素细胞瘤的良恶问题

Clinical and Histopathological Studies of Melanocytoma of the Optic Disc

目的:探讨有助于确定视盘黑色素细胞瘤恶变的临床特征。方法:回顾性分析10例临床资料和3例病理资料。结果:良性的黑色素细胞瘤可以出现视力下降、视野缺损、玻璃体色素播散、肿瘤的神经纤维层蔓延和黄斑渗出。结论:相关临床症状和体征的发展似乎并不一定提示该良性肿瘤的恶变,除非它们伴有肿块的迅速生长和肿瘤表面颜色的明显改变。眼科学报2000;16:112-115。

Objective: To examine the clinical features that may be useful in determining the malignant transformation of a melanocytoma of the optic disc. Methods: The clinical documentation of 10 cases, including visual acuity, visual field, fundus findings and fluorescein angiogram were analyzed retrospectively. Three of them undergone histopathologic examinations. Results: A benign melanocytoma may have some degree of decreased visual acuity, progressive nerve fiber bundle defect, certain amount of pigment dispersion into the vitreous, slight macular exudation and extension of the tumor tissue into the peripapillary area of the retina. Conclusion: The progression of the associated clinical symptoms and signs appears to be not necessarily indicative of a malignant transformation of the benign disease unless they are associated with rapid enlargement of the tumor mass as well as marked pigmentary changes of the tumor surface. Eye Sciene 2000; 16: 112 - 115.