不同年龄冠心病病变特点及脑钠肽的预测价值

The characteristics of people with coronary heart disease (CHD) in different age groups and the predictive value of brain-type natriuretic peptide (BNP) in CHD

目的回顾分析不同年龄冠心病临床特点及脑钠肽水平(brain-type natriuretic peptide,BNP),探讨冠心病危险因素及BNP对冠心病诊断的预测价值。方法选取经冠脉造影确诊冠心病并检验BNP患者247例,用方差分析比较危险因素及BNP与年龄、冠脉病变的关联性。结果①青年组男性比例高于老年组;患糖尿病比例随年龄增加;老年组病变支数及BNP水平高于青年组;BNP水平与年龄呈正相关。②三支病变组年龄及BNP水平高于青年组;患糖尿病比例随病变支数增加;BNP水平与病变支数呈正比。③单支病变比例随年龄增长而降低;三支病变与之相反(P<0.05,P<0.01)。结论①男性冠心病发病年龄可能早于女性。②冠脉病变支数、伴发糖尿病比率及BNP水平随年龄增长而升高。③BNP有助于评估冠脉受累程度,对冠心病可能有预测价值。

[ Objective ] This objective was to perform a meta-analysis of clinical and BNP characteristics of people with CHD in different age groups , investigate the correlation among different age groups, CHD risk factors and BNP on the diagnosis of CHD predictive value. [ Methods ]247 cases of coronary heart disease confirmed by coronary angiography and BNP test were selected for comparing the risk factors and the BNP and age, coronary lesions correlation. [ Results ] （1）The proportion of male in junior group was 90.9%, obviously higher than that in elder group （P 〈0.05）; while age grew, the proportion of diabetes mellitus increased too; the mean number of coronary artery lesion in elder group was （2.07±0.85）, which was obviously higher than that in junior group （P〈 0.05）; the mean value of BNP in elder group was （365.55±645.9） mmol/L, which was markedly higher than that in junior group （P 〈0.05）; Through spearman rank correlation, BNP and age were positive correlation （P 〈0.01）. （2）The mean age in three coronary artery lesion group was （63.17±10.42） years, obviously higher than that in group （P〈 0.01）; while the number of coronary artery lesion grew, the proportion of diabetes mellitus increased too （P 〈0.01）; the mean value of BNP in three coronary artery lesion group was （376.49±647.1） mmol/L, which was markedly higher than that in single lesion group （P 〈0.05）; through spearman rank correlation, BNP and number of coronary artery lesions were positive correlation （P 〈0.01）. （3）The proportion of single lesion decreased with age growing, on the contrary, the proportion of three lesion increased with age growing （P 〈0.05）. [ Conclusion] （1）Age of CHD onset in male may be earlier than that in female. （2）Number of coronary artery lesion, proportion of diabetes mellitus and BNP value all increased with the age. （3）BNP value contributed to evaluating the degree of coronary artery lesion, and BNP value may predict CHD.