细菌性阴道病对妊娠结局的影响

Effects of bacterial vaginosis on the outcomes of pregnancy.

目的 :确定细菌性阴道病 (BV)在妊娠妇女中的发病情况及对母婴的不良影响。方法 :以四项临床诊断指标中符合 3项并阴道涂片革兰染色细菌评分≥ 7分作为BV的诊断标准 ,对 40 6名初次产检的孕妇进行BV的筛查 ,追踪其中 34名单纯合并BV者和 2 5 2名无BV者的妊娠结局。结果 :1 妊娠期BV的发病率为 11 82 % ,其在中孕早期的患病率为9 72 % ,孕晚期患病率为 14 2 8%。 2 有BV组的早产、组织学绒毛膜羊膜炎和新生儿高胆红素血症发生率分别为 14 71%、8 82 %和 5 5 88% ,高于无BV组 ,分别为 3 17%、0 79%和 34 13 % ,P =0 .0 0 7、P =0 .0 13、P =0 .0 2 3。结论 :BV是妊娠妇女最常见的阴道感染性疾病之一 ,其与早产、组织学绒毛膜羊膜炎和新生儿高胆红素血症等不良妊娠结局有关 ,有必要对孕妇进行BV的筛查和治疗。

Objective:To determine the prevalence of bacterial vaginosis (BV) is pregnant women and to assess its adverse effect on maternal and neonate.Methods:BV was screened in 406 healthy pregnancy women attend the antenatal clinic at their first visit.The diagnosis criteria for BV was presence of three of four clinical signs and the score of 7 or higher using a standardized scoring system for the interpretation of Gram?stained vaginal smears.The pregnancy outcomes of 34 pregnant women with BV and 252 without BV were followed up.Results:1.The prevalence of BV in pregnant women was 11.82%,in early of the second trimester was 9.72%,and in the third trimester was 14.28%.2.The incidence of preterm labor,histologic chorioamnionitis,and hyperbilrubinemia of neonate was higher in women with BV than those without BV (14.71%,8.82%,and 55.88% V.S.3.17%,0.79%,and 34.13%,respectively.P=0.007,P=0.013,P=0.023).Conclusions:BV is one of most common vaginal infections in pregnant women,and is associated with increased rates of preterm delivery,histologic chorioammionitis,and hyperbilirubinemia of neonate.It is necessary to screen and treat BV during pregnancy