辽宁省155例唇、腭裂患儿再发风险及危险因素分析

Analysis of recurrent probability and risk factors of 155 handicapped children with cleft lip and cleft palate.

本文对辽宁省城乡 15 5例唇腭裂病残儿进行流行病学调查 ,结果表明 ,唇腭裂疾病的再发风险率为 3 5 7% ;病残儿母亲有 12 38%既往不良妊娠史、本次先兆流产 9 0 3%、31 6 1%妊娠并发症、19 35 %孕期接触理化环境、34 19%孕期感染、2 6 45 %孕期服药 ;病残儿父亲 19 35 %接触理化环境、8 38%感染、1 94%长期服药。经与后天伤残对照组进行单因素和多因素回归分析 ,遗传因素、患儿母亲孕期母亲用药、孕期父母患感染是导致唇腭裂的主要危险因素。

The epidemiological investigation of 155 handicapped children with cleft lip and cleft palate was done.The results showed that recurrent probability of them was 3.57%.There were 12.38% abnormal pregnant cutcome histories,9.03% threatened abortion this time,31.61% pregnant complication of handicapped children′s mothers;19.35% involment physical and chemical factors,34.19% in infectious factors,and 26.45% with history of drugs intaking during their mother′s pregnancy.There were 19.35% involment physical and chemical factors,8.38% in infectious factors,and 1.94% with history of long period of drugs intaking of their father.Logistic regression analysisdemonstrated that major risk factors for handicapped children with cleft lip and cleft palate were hereditary factor,drugs usingduring pregnancy,pregnancy infections of handicapped children′s parents.