福建省艾滋病流行态势及影响因素的分析

The Characteristic and Tendency of AIDS Epidemic in Fujian

[目的 ]研究福建省艾滋病流行态势及其影响因素。[方法 ] HIV抗体检测、流醒病学调查及 HIV亚型鉴定。[结果 ]共检测 780 2 2 9份标本 ,HIV抗体阳性 131例 ,检出率 0 .169‰。其中 AIDS病人 4 1例 ,已死亡 3 7例。流行病学调查确定福建 HIV/AIDS病例主要分布在福州、泉州和厦门等经济较发达的沿海地区。以境外感染为主 ,并向境内蔓延扩散。主要感染途径是异性性接触。分析 32例病人的临床资料 ,表明其存活期短 ,早期症状以持续或反复发热为主。HIVC2 -V3区核苷酸序列分析证实 HIV-1E亚型为本省主要流行株。 [结论 ]福建艾滋病今后流行将主要经性途径 ,但在静脉吸毒人群中也存在

Objective ] To study characteristic and tendency of AIDS epidemic in Fujian. [Methods] The total 780 229 serum samples from high risk group and specific population such as blood donors and people that go abroad and come back were examined for anti HIV antibody. HIV epidemic investigation was carried out, and HIV 1 subtype was identified by nucleotide sequence analysis. [Results] The positive rate was 0.169‰(131/780 229), among them 41 cases were AIDS patients and 37 cases died. The HIV/AIDS cases were mainly distributed in Fuzhou, Quanzhou and Xiamen cities. The most cases were infected abroad and the numbers of HIV carriers infected by heterosexual contacts in the province were increasing in recent years. Clinical data of 32 patients with AIDS showed that early symptoms was sustained and reversal fever, and survival time for them was shorter. Sequence analysis of C2 V3 region PCR amplified from the PBMCs showed that HIV 1 strains epidemic in the province were dominant with subtype E. [Conclusion] HIV infection are mostly by sexual transmission in Fujian and there exists the risk of spreading HIV in injecting drug users.