舒尔通合剂止吐和抑制食管上皮增生实验的研究

Study of Prevent Vomiting and Esophageal Epithelial Hyperplasia Inhibition Effect of Shu Er Tong He Ji

目的观察舒尔通合剂止吐、对食管上皮增生的作用。方法家鸽静脉注射硫酸铜制作呕吐动物模型,舒尔通灌胃后观察药物防止呕吐的作用;手术方法制作大鼠食管反流模型,应用滴灌到胃的给药方法观察对大鼠食管上皮组织增生的影响。结果舒尔通合剂能对抗硫酸铜引起的家鸽的呕吐,与对照组比较呕吐次数及呕吐潜伏时间差异有统计学意义(P<0.01);HE染色显示舒尔通合剂能减少由于食管反流引起的上皮损伤。结论舒尔通合剂具有防止呕吐的作用,并能明显改善食管上皮由于反流造成的组织损伤。

OBJECTIVE To observe the role of the Shu Er Tong He Ji in preventing vomiting and inhibiting of esophageal epithelial hyperplasia. METHODS Vomiting animal model was established by CuSO4 intraveneus injection in pigeon. The vomiting precent role was observed by drip delivery of Shu Er Tong He Ji. Rats esophaged reflux model was produced by operation. The influence of drug on epithelial tissue hyperplasia was observed by drip irrigation. RESULTS The Shu Er Tong He Ji could relieve the vomit caused by CuSO4, it has significant difference compared with control group on the frequency of vomiting and vomiting latent time （P〈0.01）; Hematoxylin eosin（HE） staining showed that The Shu Er Tong He Ji can reduce the epithelial damage cause by esophageal reflux. CONCLUSION The Shu Er Tong He Ji might prevent vomiting and improve the esophageal epithelium due to tissue damage caused by the reflux.