我院烧伤科2009年-2012年10月抗菌药物应用分析

Analysis of the Utilization of Antibacterials in Department of Burn from Our Hospital from 2009 to Oct. 2012

目的:评价我院烧伤科抗菌药物的应用情况。方法:对我院烧伤科2009年-2012年10月抗菌药物的销售金额、用药频度(DDDs)等进行统计、分析;并随机抽取400份住院患者病历,分析其病原学送检率、病原菌分布、耐药情况及抗菌药物的使用情况。结果:我院烧伤科抗菌药物的销售金额呈逐年上升趋势,位居前3位的分别为碳青霉烯类、头霉素类和糖肽类。2009年,DDDs排序列前3位的是盐酸左氧氟沙星氯化钠注射液、硫酸庆大霉素注射液和注射用头孢吡肟;2010年,DDDs排序列前3位的是注射用头孢吡肟、注射用头孢米诺钠和盐酸左氧氟沙星氯化钠注射液;2011年-2012年10月,DDDs排序列前3位的是注射用头孢呋辛钠、注射用头孢西丁钠和注射用头孢米诺钠。400份病历总的病原学送检率达38.00%。病原菌分布情况为金黄色葡萄球菌占首位,其次为铜绿假单胞菌和鲍曼不动杆菌。金黄色葡萄球菌对万古霉素无明显耐药,铜绿假单胞菌和鲍曼不动杆菌对碳青霉烯类耐药率较低。结论:我院烧伤科抗菌药物应用品种与病原菌分布、药敏试验结果基本相符,应用合理性有待进一步加强。

OBJECTIVE： To evaluate the utilization of antibacterials in department of burn from our hospital. METHODS： Con- sumption sum and DDDs of antibacterials in our hospital from 2009 to Oct. 2012 were analyzed statistically in the list of consump- tion sum, DDDs, etc. The medical records of 400 inpatients were collected randomly. The etiology inspection rates, distribution of pathogenic bacteria, drug resistance aiad use of antibacterials were analyzed. RESULTS： The consumption sum of antibacterials in- creased year by year. Carbopenem, carbapenems and glycopeptides took up the first places. In term of DDDs, Levofloxacin sodium chloride injection, Gentamicin sulphate injection and Cefepime for injection ranked the top 3 places in 2009; Cefepime for injec- tion, Cefrninox sodium for injection and Levofloxacin sodium chloride injection ranked the top 3 places in 2010; Cefuroxime sodi- um for injection, Cefoxitin sodium for injection and Cefminox sodium for injection ranked the top 3 places from 2011 to Oct. 2012. Etiology inspection rates were 38 %, and Staphylococcus aureus occupied the first place, followed by Pseudomonas aeruginosa and Acinetobacter baumannii. S. aureus was little resistant to vancomycin, and P aeruginosa and A. baumannii were less resistant to car- bapenems. CONCLUSIONS： The category of antibacterials is basically consistent with distribution of pathogenic bacteria and drnz-susceotibilitv test in our hosoital, and rational use of antibacterials remains to be further strengthened.