我院超说明书用药情况分析与分级管理

Analysis and Classification Management of Off-label Drug Use in Our Hospital

目的:了解我院超说明书用药现状,探讨合理、可行的处理对策,促进临床合理用药。方法:随机抽取我院2012年1-9月门诊(急)处方47861张、静脉药物配置中心医嘱81030条。以药品说明书为依据,分别对处方或医嘱中的适应证、人群适宜性、给药剂量、频次、溶媒及配制浓度等方面进行分析,采用Excel软件进行数据处理;最后将超说明书用药问题根据可能对患者造成伤害的风险程度进行分级管理。结果:本次调查共发现超说明书用药处方876张,超说明用药医嘱366条,整理得到超说明书用药问题32条。结论:对超说明书用药实行分级管理,既能满足临床用药需求,又能促进用药的安全合理,值得推广。

OBJECTIVE： To investigate the situation of the off-label drug use in our hospital, and to find a feasible and practi- cal way to promote clinical rational drug use. METHODS： 47 861 outpatient （emergency department） prescriptions and 81 030 or- ders from P1VAS were collected from our hospital during Jan.- Sept. in 2012. According to package inserts, rationality evaluation had been done in indications, suitable groups, dosage and frequency, solvent and preparation concentration. Excel software was used for data processing. The off-label drug use were classified according to the risk degree. RESULTS ： In this investigation, off-la- bel drug use was found in 876 prescriptions and 366 orders, including 32 problem items. CONCLUSIONS： Classification manage- ment of the off-label drug use not only can meet the needs of clinical drug use but also can improve the rational use of drugs. KEY WORDS