气相色谱法测定四氢苯酐中杂质马来酸酐

Determination of maleic anhydride in tetrahydrophthalic acid anhydride by gas chromatography

建立了气相色谱法测定四氢苯酐中杂质马来酸酐含量的分析方法。样品经乙腈超声溶解后,用气相色谱分析,外标法定量。目标物马来酸酐在0.25～20.0 mg/L范围内线性关系良好(r=0.9999),检测限(S/N=3)为0.10 mg/L,在25、500和1000 mg/kg的3个添加水平下,目标物的平均回收率为99.4%～108.0%,相对标准偏差(n=6)为0.85%～3.6%。

An analytical method based on GC has been established for the determination of maleic anhydride impurity in tetrahydrophthalic acid anhydride. The sample was dissolved in acetonitrile with ultrasonic processing, detected by GC and quantified by the external standard method. The calibration curve for the target analyte was linear in the range of 0. 25 ~ 15.0 mg/L （r = 0. 9999）, and the limit of detection （S/N = 3 ） was 0. 10 mg/L. The mean recoveries of the target analyte at the spiked levels of 25,500 and 1000 mg/kg were 99.4% - 108.0% with the relative standard deviations（ n = 6） of 0.85% ~ 3.6%.