1,6-二磷酸果糖钠盐化学稳定性的研究

Stability of Sodium Fructose-1,6-diphosphate Powder

目的 :研究 1,6 二磷酸果糖钠盐粉针剂的化学稳定性 ,探讨其内在质量。方法 :依据化学动力学原理 ,用酶法测定含量 ,采用经典恒温法 ,测定此品的降解速度常数 (k) ,并由Arrhenius公式计算产品有效期。结果 :1,6 二磷酸果糖钠盐粉针剂的分解在 5 0℃和 60℃时符合零级动力学方程 ,在 70℃时符合一级动力学方程。结论 :1,6 二磷酸果糖钠盐粉针剂的T2 5℃0 .9不能用Arrhenius公式计算 ,应用留样观察方法确定产品的有效期。

Purpose:To investigate chemical stability of sodium fructose 1,6 diphosphate(FDP) powder and to control its quality.Methods:The constant temperature acceleration test was used according to the principles of chemical dynamics.FDP content was determined by enzymatic method.The reaction rate constant ( k) and its term of validity was calculated by Arrhenius equation.Results:The data showed that the kinetics of FDP powder followed the zero order reaction at 50℃and 60℃,or the first order reaction at 70℃ respectively.Conclusion: T 25℃ 0.9 of FDP powder can′t be calculated by Arrhenius formula,and its term of validity should be inferred from the results obtained from the samples preserved at room temperature,since it followed different orders at different temperatures.