吉兰-巴雷综合征患者血清和脑脊液中P2蛋白抗体检测及其临床意义

Detection of P2 antibodies from serum and CSF in patients with Guillian-Barre syndrome and its clinical significance.

目的 评价P2蛋白抗体在辅助吉兰 巴雷综合征 (GBS)临床诊断中的价值。方法 用ABC -ELISA方法检测 64例血清和CSF配对的GBS病人样品中IgG和IgM型P2抗体水平。结果 GBS患者CSF中IgM型P2抗体阳性率明显高于其它神经系统疾病组和正常对照组(P <0 0 1 ) ,且重症型GBS病人高于轻症型病人 (P =0 0 0 1 9) ,血清与CSF间P2抗体水平无相关性。结论 GBS病人CSF中存在P2特异性免疫球蛋白 。

Objective To evaluate the role of P2 protein antibody in the diagnosis of Guillian Barre syndrome (GBS) in clinical practice. Methods The levels of P2 protein antibodies in paired CSF and serum of 64 GBS patients were measured by ABC ELISA.Results Compared to patients with other neurological diseases and normal control group, the Positive rates of the IgM P2 antibodies in CSF was much higher in GBS groups( P <0.01), and correlated significantly with the severity of the disease. The levels of P2 antibodies have no relationship between CSF and serum. Conclusions Our results indicate that detection of IgM P2 antibody in CSF may be useful in the clinical diagnosis of GBS, and that P2 antibody in CSF of GBS patiensts may play an important role in the mechanisms of immune damage.