水相法合成高取代度辛烯基琥珀酸淀粉脂及其莪术油乳液的制备

Study of Water-soluble Synthesis of Starch Sodium Octenyl Succinate(SSOS) with High Degree of Substitution(DS) and Preparation of Emulsification of Zedoary Oil

目的:水相法合成高取代度的辛烯基琥珀酸淀粉酯(SSOS),并选取莪术油为模型药物,考察SSOS-莪术油乳液的稳定性。方法:采用水相合成法,在淀粉量一定的条件下,改变酸酐用量、反应温度、酸酐滴加时间,并确定最佳合成条件。考察不同取代度、糊液浓度、芯壁比条件下,SSOS-莪术油乳液的乳化性能。结果:在原淀粉用量100 g,反应温度50℃,反应时间4 h,酸酐用量35 g的条件下,合成取代度达到0.083的SSOS。在SSOS取代度为0.07,乳液浓度为0.05,芯壁比为0.17的条件下,测得莪术醇的包封率为100.00%(全包封),β-榄香稀的包封率为34.891%。结论:通过对反应条件的优化,可以采用水相法合成高取代度SSOS,最高取代度达到0.083,且SSOS-莪术油乳液具有良好的稳定性和包封率。

This study was aimed to investigate water-soluble synthesis of starch sodium octenyl succinate （SSOS） with high degree of substitution （DS） and emulsion stability of SSOS-Zedoary oil. The content of acid anhydride, reaction temperature and time was investigated with water-soluble synthesis method. Emulsification of SSOS-Zedoary oil was also investigated with different SSOS, core-to-wall ratio and concentration. The results showed that DS with 0.07, concentration with 0.05 and core-to-wall ratio with 0.17 was beneficial for increasing the encapsulation efficiency and stability of emulsification. The microencapsulation efficiency was 100.00% for Curcumol and 34.891% for β-elemene, respectively. It was concluded that high DS （0.083） of SSOS can be synthesized by water-soluble method. Emulsification of SSOS-Zedoary oil was also stable.