拼合原理在降压新药研发中的应用构想

Combination Principles and Their Application in the Research and Development of New Antihypertensive Drugs

因高血压发病机制较为复杂、发病机理不甚明确等,导致对其治疗和控制已成为当今临床迫切需要解决的难题。近年来,人们已逐步认识到要想达到理想的降压效果,联合用药已成为必然选择。若利用拼合原理,将两个降压药物的基本结构拼合在一个分子中,有望获得毒副作用小、药理效应相加的降压新药。该应用构想不仅可为联合用药开辟一条新的途径,也可体现联合用药新的发展趋势。

Hypertension, as a primary dangerous factor of cardiovascular and cerebrovascular diseases, has become a heavy burden to the family and country. Due to complicated aetiological agent and unclear pathogenesis, the treatment and management of hypertension have become an urgent need in the clinical practice. In recent years, people have realized that if they want to achieve the desired antihypertensive effect, drug combination becomes an inevitable choice. If we use combination principles which assembling two basic structures of anti-hypertension drug in one molecule, we will obtain the new antihypertensive drugs with decreased toxic side effects and in- creased pharmacological effect .This application will not only open up a new way for drug combination, but also reflect a new development trends of drug combination.