壮骨胶囊对原发性骨质疏松症中医证候群及骨密度水平的影响

Influence on TCM Syndrome and Bone Mineral Density Level in Osteoporosis by Zhuanggu Capsule

目的:观察壮骨胶囊对于原发性骨质疏松症患者中医证候群及对骨密度水平的影响,并评价其临床疗效。方法:将80例原发性骨质疏松症患者按随机、平行对照的方法随机分为治疗组和对照组,治疗组予壮骨胶囊治疗,对照组予乐力钙治疗记录治疗前后患者的中医证候评分及腰椎和股骨颈的骨密度变化,并评价临床疗效。结果:治疗组总有效率为95.0%,对照组总有效率为80.0%,两组疗效比较,治疗组优于对照组,差异有统计学意义(P<0.05);两组治疗后中医证候积分均低于治疗前(P<0.05);治疗后中医证候积分比较,治疗组低于对照组(P<0.05);两组治疗后骨密度均高于治疗前(P<0.05),且治疗后骨密度比较,治疗组高于对照组(P<0.05)。结论:壮骨胶囊治疗原发性骨质疏松症有显著临床疗效,能有效增加骨密度,显著改善中医证候。

Objective ：To Observe the influence of Zhuanggu capsule on TCM syndrome of traditional Chinese medicine on bone mineral density and level of influence in primary osteoporosis and evaluate the clinical efficacy. Methods： 80 patients with primary osteoporosis patients were randomized into treatment and control group with parallel comparison method; patients in the treatment group were treated with Zhuanggu capsule, and that of the control group were given Compound Calcium Amino Acid Chelate Capsules. The TCM symptoms score, lumbar and femoral neck BMD were observed to evaluate the clini- cal efficacy. Results： The total effective rate in the treatment group was 95.0%, and that of the control group was 80.0%; the curative effect of the treatment group was better than that of the control group（P〈0.05）; The TCM symptoms score in both of two groups reduced after the treatment（P〈0.05）; and the BMD in treatment group was lower than that of the control group af- ter the treatment（P〈0.05）; The TCM symptoms score in both of two groups reduced after the treatment（P〈0.05）; and the BMD in treatment group was lower than that of the control group after the treatment（P〈0.05）. Conclusion： Zhuanggu capsule can provide effectively curative effect for osteoporosis, increase the bone density and improve the TCM symptoms.