赖诺普利治疗原发性轻中度老年高血压

Lisinopril in treating mild to moderate primary hypertension in the elder

目的 :观察赖诺普利治疗原发性轻、中度老年高血压的疗效及不良反应。方法 :76例轻、中度原发性老年高血压病人 ,分为赖诺普利组 4 6例 ,用赖诺普利 2 0～ 30mg ,po ,qd。吲哒帕胺组 30例 ,用吲哒帕胺 2 .5～ 5mg ,po ,qd ,均维持治疗 8wk。结果 :赖诺普利组总有效率 85% ;吲哒帕胺组总有效率 57%。 2组差异有非常显著意义 (P <0 .0 1)。 2组治疗前后收缩压 /舒张压下降分别为 (4 .0± 1.6 )kPa/ (2 .3± 1.1)kPa和 (2 .4± 1.0 )kPa/ (1.3± 1.1)kPa ,2组差异有非常显著意义 (P <0 .0 1)。结论 :赖诺普利治疗轻、中度老年高血压疗效优于吲哒帕胺 ,可作为治疗原发性轻、中度老年高血压的一线药物。

AIM: To observe the efficacy of lisinopril in treating mild to moderate primary hypertension in the elder. METHODS: Seventy six older patients suffering from mild to moderate primary hypertension were treated with lisinopril 20-30 mg·d -1 (46 patients) or with indapamide 2.5-5 mg·d -1 (30 patients) for 8 wk. RESULTS: The effective rate in lisinopril group was 85%, higher than that (57%) of indapamide group ( P <0.01). The decrease of the systolic and diastolic blood pressure were (4.0±1.6)kPa/(2.3±1.1)kPa and (2.4±1.0)kPa/(1.3±1.1)kPa separately. There was an obvious difference between the two groups ( P < 0.01 ). CONCLUSION: The efficacy of lisinopril in treating mild to moderate primary hypertension in the elder is better than indapamide and it may be the first line drug in treating mild to moderate primary hypertension in the elder.