MMP-2、MMP-9与肺癌发生、转移的现状及进展

Status and development on relationship between matrix metalloproteinase-2, matrix metalloproteinase-9 and occurrence and invasion metastasis of lung cancer

基质金属蛋白酶（MMPs）又称间质蛋白酶，许多疾病如骨关节炎、多发性硬化、肿瘤等都伴随着MMPs活性的改变，其中以MMPs在恶性肿瘤侵袭转移中的作用最引人注目。本文就MMPs家族中MMP-2、MMP-9与肺癌的发生、转移的现状及进展作一综述。

Matrix metalloproteinases （MMPs） are also known as matrixins. Many diseases,such as osteoarthritis,multiple sclerosis, and cancer, are accompanied by changes of activity of MMPs. MMPs play roles in invasion and metastasis of malignant tumors. This article reviews the status and development on relationship between MMP-2,MMP-9 and the occurrence and metastasis of lung cancer.