Fas蛋白与非小细胞肺癌关系的研究进展

Fas protein and non-small cell lung cancer

目前非小细胞肺癌（NSCLC）发生、发展及转移机制的研究不断深入，关于NSCLC中Fas及Fas配体（FasL）蛋白的表达以及其介导的凋亡、免疫逃逸在肺癌发生发展、转移及预后中的作用机制研究不断涌现。探讨Fas-FasL系统在NSCLC发生发展中所起的作用，可为临床早期诊断肺癌、判断预后、设计新的治疗策略提供依据。

With the rapid growth of incidence of non-small cell lung cancer （ NSCLC）, more and more studies have been made about its occurrence, development and metastatic mechanism in recent years. Researches about Fas/FasL protein expression and Fas/FasL-mediated apoptosis, immune escape mechanism and their roles in the pathogenesis, progression and prognosis of lung cancer are constantly emerging. Discussion about the roles of Fas/ FasL system in NSCLC could provide evidence for early diagnosis, prognosis prediction and new treatment of NSCLC.