核医学显像与胰腺内分泌肿瘤的诊断和治疗

Nuclear medical imaging in the diagnosis and treatment of endocrine pancreatic tumors

胰腺内分泌肿瘤（EPTs）是一组具有不同临床表现、生物学行为以及预后的肿瘤的总称；其显著特征为大部分肿瘤细胞存在神经胺摄取机制和（或）细胞表面表达特殊受体，这些都为核医学显像在诊疗EPTs方面提供了依据。随着核医学技术的发展，尤其是PET与CT实现了解剖与功能的完美结合，核医学显像在探查EPTs微小病灶、早期发现转移灶以及治疗方面具有独到的优势。

Endocrine pancreatic tumors （EPTs） are a heterogeneous group of neoplasms with variable manifestations, biological features and prognosis, which are characterized by the presence of neuroamine uptake mechanisms and （or） peptide receptors on the cell membrane. All these features constitute the basis for the clinical use of nuclear medicine examination methods, both for imaging diagnosis and therapy. With the development of nuclear medicine technologies, especially the exquisite hybrid positron emission tomography/ computed tomography （PET/CT）, bringing about perfect combination with anatomic location and functional metabolism ,they have specific advantages for small lesion probe, early metastasis detection and therapy.