脂肪细胞型脂肪酸结合蛋白与2型糖尿病的关系被引量：2

Association between FABP4 and type 2 diabetes mellitus

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摘要脂肪细胞型脂肪酸结合蛋白（FABP）4是脂肪酸结合蛋白家族中的一员，主要在脂肪细胞和巨噬细胞中表达，其表达受胰岛素、过氧化物酶体增殖物活化受体（PPAR）-γ激动剂的调控，可调节机体炎性反应，在体内脂肪酸转运和能量代谢中起重要作用。研究发现，FABP4能增加2型糖尿病的风险，预测血糖水平。同时，FABP4与2型糖尿病危险因素及糖尿病并发症的发生、发展也密切相关。 Adipocyte fatty acid-binding protein （FABP）4 blongs to a family of fatty acid-binding proteins, which is mainly expressed in adipocytes and macrophages. The expression of FABP4 can be regulated by insulin and peroxisome proliferator-activated receptor-gamma （PPAR）-γ agonist. It could modulate inflammatory responses and was thought to be important in mediating intracellular fatty acid trafficking and energy metabolism. It was observed that FABP4 could increase the risk of type 2 diabetes mellitus and predict glycemic level. At the same time, FABP4 was significantly associated with occurrence and development of the risk factors of type 2 diabetes mellitus and its complications.

作者杨莉丽于雪梅

机构地区南方医科大学第三临床医学院南方医科大学附属奉贤医院内分泌代谢科

出处《国际内分泌代谢杂志》北大核心 2013年第2期122-125,共4页 International Journal of Endocrinology and Metabolism

基金上海市卫生局资助项目（2009225）上海中医学重点专科建设计划（ZK2012B16）

关键词脂肪细胞型脂肪酸结合蛋白(FABP)4 炎症能量代谢 2型糖尿病 Adipocyte fatty acid-binding protein Inflammatory responses Energy metabolism Type 2 diabetes mellitus

分类号 R587.1 [医药卫生—内分泌]

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参考文献29

1Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins:role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov ,2008,7:489-503.
2金静,彭道泉.脂肪细胞型脂肪酸结合蛋白与动脉粥样硬化的研究进展[J].中国动脉硬化杂志,2009,17(4):327-330. 被引量：3
3Tsuda M, Inoue-Narita T,Suzuki A,et al. Induction of gene encoding FABP4 in Pten-null keratinocytes. FEBS Lett, 2009,583: 1319-1322.
4Wang XQ, Yang K, He YS, et al. Receptor mediated elevation in FABP4 levels by advanced glycation end products induces choles- terol and triacylglycerol accumulation in THP-1 macrophages. Lipids ,2011,46:479486.
5Song J, Ren P, Zhang L, et al. Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4. Biochem Biophys Res Commun, 2010,393:89-94.
6Ahn J, Lee H, Kim S, et al. Curcumin-indueed suppression of adipogenic differentiation is accompanied by activation of Wnt/beta- catenin signaling. Am J Physiol Cell Physiol, 2010, 298: C1510-C1516.
7Sommer G, Ziegelmeier M, Bachmann A, et al. Serum levels of adipocyte fatty acid-binding protein (AFABP) are increased in chronic haemodialysis (CD). Clin Endocrinol (Oxf) ,2008,69 : 901-905.
8Ayers SD,Nedrow KL, Gillilan RE, et al. Continuous nucleocytoplasmic shuttling underlies transcriptional activation of PPARgamma by FABP4. Biochemistry,2007,46:6744-6752.
9Gillilan RE, Ayers SD, Noy N. Structural basis for activation of fatty acid-binding protein 4. J Mol Biol,2007,372 : 1246-1260.
10Hui X, Li I-I, Zhou Z, et al. Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a posi- tive feedback loop involving c-Jun NH2 -terminal kinases and acti- vator protein-1. J Biol Chem,2010,285:10273-10280.

二级参考文献24

1Hotamisligil GS. Inflammation and metabolic disorders [ J ]. Nature, 2006, 444 (7121) : 860 - 867,
2Chmurzynska A. The muhigene family of fatty acid binding protein ( FAB-Ps) : Fuction, structure and polymorphism [ J ]. J Appl Genent, 2006, 47 (1) : 39-48.
3Shum BO, Mackay CR, Gorgun CZ, et al. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation [J]. J Clin lnvest, 2006, 116 (8) : 2 183-192.
4Xu Y, lyengar S, Roberts RL, et al. Primary culture model of peroxisome proliferators activated receptor gamma activity in prostate cancer ceils [J]. JCeUPhysiol, 2003, 196 (1) : 131-143.
5Perrella MA, Penacani A, Layne MD, et al. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice [ J ]. FASEB J, 2001, 15 ( 10 ) : 1 774- 776.
6Hotamisligil GS, Johnson RS, Distel R J, et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein [J]. Science, 1996, 274 (5291) : 1 377-379.
7Makowski L, Boord JB, Maeda K, et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis [ J ]. Nat Med , 2001,7 (6) : 699-705.
8Layne MD, Patel A, Chen YH, et al. Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice [ J ]. FASEB J, 2001, 15 (14) : 2 733-735.
9Boord JB, Maeda K, Makowski L, et al. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia [ J ]. Arterioscler Thromb Vasc Biol, 2002, 22 (10) : 1 686-691.
10Furuhashi M, Tuncman G, Gorgun CZ, et al. Treatment of diabetes and atheroclerosis by inhibiting fatty-acid-binding protein aP2 [J]. Nature, 2007, 447 (7147) : 959-965.