两种治疗方法对乳癌患者血清可溶性白介素Ⅱ受体水平的比较研究

Comparative study of two therapeutic methods on soluble interleukin 2 receptor level in serum of patients with breast cancer

目的 探讨乳癌患者单纯手术和化疗再手术后血清可溶性白介素Ⅱ受体水平对预后的临床意义。方法 采用双抗体酶联免疫吸附法对 5 0例正常人、5 0例乳癌单纯手术患者与 68例乳癌化疗再手术患者血清可溶性白介素Ⅱ (SIL 2R)水平进行了测定。结果 乳癌患者血清SIL 2R显著高于正常人 (P <0 .0 1) ,单纯手术后和化疗 3周再手术后患者血清SIL 2R水平分别为 ( 5 2 6.5 2± 2 45 .77)U/ml与( 4 3 2 .14± 167.3 6)U/ml。两种治疗方法差异有显著性 (P <0 .0 5 )。结论 提示乳癌患者化疗后再手术切除对预后有十分重要的意义。

Objective The exploration of surum soluble interleukin 2 receptor level and clinical meaning of prognosis on the patients with breast cancer treated operated by surgical operation alone or by surgical operation after chemical treatment.Method A two layer antibody sandwich enzymelinked immunosorbent assay(ELISA) was used to measure the serum soluble interleukin 2 receptor(SIL 2R) level in 50 healthy individuals and 50 patients with breast cancer who were treated with surgery alone as well as 68 patients treated with surgery after 3 weeks of chemical treatment.Results The serum SIL 2R level of the patients with breasts cancer is much higher than that of healthy individuals(P<0.01).The serum SIL 2R levels of the patients with and without chemical treatment are 526.52±245.77 and 432.14±167.36 U/ml respectively.There is an obvious difference between the two groups(P<0.05).Conclusion It is suggested that the patients with breast cancer should be given chemical treatment before surgery.