空肠弯曲菌感染与Guillain-Barr综合征

CAMPYLOBACTER JEJUNI INFECTION AND GUILLAIN-BARRSYNDROME

目的：探讨空肠弯曲菌感染与Ｇｕｉｌｌａｉｎ－Ｂａｒｒｅ综合征（ＧＢＳ）发病的关系以及空肠弯曲菌感染和抗－ＧＭ１抗体与疾病严重程度的关系。方法：用ＥＬＩＳＡ方法检测８５例ＧＢＳ患者血清中的空肠弯曲菌ＩｇＧ、ＩｇＭ、ＩｇＡ抗体及抗－ＧＭ１抗体，同时从患者的大便中培养空肠弯曲菌；根据Ｈｕｇｈｅｓ报道的方法对病情轻重进行评分。结果：ＧＢＳ患者空肠弯曲菌感染率为５１．８％，抗－ＧＭ１抗体检出率为４２．４％；

Objective:To study the relationship between campylobacter jejuni(Cj) infection and Guillain-Barré syndrome(GBS),and the relationship between Cj infection or anti-GM1 antibody and disease severity.Methods:The method of ELISA was used to detect the antibodies (IgG,IgM,IgA) to Cj and anti-GM1 antibody in the serum of 85 patients with GBS.At the same time,stool cultures for Cj were also performed.Disease severity was assessed by the Hughes reported method.Results:The recent infection rate of Cj in GBS patients was 51.8%,and the detection rate of anti-GM1 anbibody was 42.4%;the detection rate of anti-GM1 antibody in the GBS patients with recent Cj infection was significantly higher than in the patients without Cj infection (P<0.001).Disease severity was not different between Cj-positive and Cj-negative or between anti-GM1-positive and anti-GM1-negative groups (all P>0.05).Conclusions:Cj infection is one of the important inducing factors in GBS;The presence of anti-GM1 antibody in the serum was associated with a recent Cj infection,but Cj infection or the presence of anti-GM1 antibody was not associated with disease severity.