肝纤维化血清学检测指标的研究进展

Research progress in serological testing indicators of clinical examination for liver fibrosis

肝纤维化是临床上多种急、慢性肝病的病理转归,其形成主要是细胞外基质代谢异常而致的组织重建、细胞因子的异常和肝损伤因子3个方面的因素。肝纤维化是一个动态发展的过程,肝硬化早期尚具有可逆转性,所以肝硬化的早期诊断具有重要的临床意义。目前的诊断方法主要有血清学、影像学和病理学,血清学是临床应用最为广泛的诊断方法,本篇重在分析总结血清学诊断方法的应用现状、研究进展,并探讨其以后的发展方向。

Being the pathological outcome of many kinds of acute and chronic liver diseases, liver fibrosis is mainly induced by 3 factors such as tissue reconstruction caused by abnormal metabolism of extracellular matrix, abnormal cytokine, and liver damage factors. Liver fibrosis is a dynamic development process. Early cirrhosis still can be re- versed, so its early diagnosis has important clinical significance. Current diagnostic methods include serological, imag- ing and pathological ways, and serological method is the most widely used diagnostic method of clinical application. This article focuses on the analysis and summary of the serological diagnostic methods application status, research progress, and exploring the direction of its future development.