宫颈上皮内瘤变治疗后人乳头瘤病毒的清除及随访

Human papilloma virus clearance and follow-up after treatment of cervical intraepithelial neoplasia

目的探讨人乳头瘤病毒清除率在宫颈上皮内瘤变(CIN)治疗前后的变化以及其与疾病预后的关系。方法对本院收治的200例宫颈上皮内瘤变患者实施环形电切术进行治疗,并进行2～5年随访,检测治疗前后清除率,并对疾病的预后情况进行分析。结果经治疗后,患者病毒清除率较治疗前显著升高(P<0.01),经随访发现病毒的清除率越低,病变的持续存在率和复发率越高。结论经环形电切术治疗后患者乳头瘤病毒的清除率明显下降,同时病毒的清除率影响患者的预后。

Objective To explore the human papilloma virus removal rate changes in cervical intraepithelial neoplasla （CIN） before and after treatment and relationship with prognosis. Methods The 200 cases of cervical intraepithelial neoplasia were treated with loop electrosurgical excision procedure for treatment, and followed up for 2-5 years, the clearance rate before and after treatment, and the prognosis of the disease were analyzed. Results After treatment, virus clearance rate of patients was higher than that before treatment （P 〈 0.01）, the follow-up revealed that virus re- moval rate was higher, lesions of the persistence and relapse rates was higher. Conclusion Human papilloma virus re- moval rate decreases after loop electrosurgical excision procedure in the treatment, while the rate of virus clearance in- fluence the prognosis of the patients.