凝血酶联合奥美拉唑治疗上消化道出血的疗效分析

Curative effect analysis of thrombin plus omeprazole for upper gastrointestinal bleeding

目的探讨凝血酶联合奥美拉唑治疗上消化道出血的疗效。方法 2011年10月～2012年10月本院共治疗上消化道出血患者80例,将其随机分为治疗组和对照组,两组均给予必要的基础治疗,并给予奥美拉唑静脉滴注,治疗组在此基础上加用凝血酶,观察两组患者的止血时间以及治疗有效率。结果治疗组止血时间为(29.61±6.13)h,显著少于对照组的(44.21±9.88)h,差异有统计学意义(P<0.05);治疗组总有效率为95.0%,对照组总有效率为80.0%,治疗组总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论凝血酶联合奥美拉唑治疗上消化道出血止血效果好,不良反应少,值得推广应用。

Objective To investigate the curative effect of thrombin plus omeprazole for upper gastrointestinal bleed- ing. Methods Total of eighty patients with upper gastrointestinal bleeding were treated in our hospital from October 2011 to October 2012, and randomly divided into treatment group and control group. Both groups were treated by nec- essary basic treatments and omeprazole intravenous infusion. On this base, the treatment group was also treated by thrombin. The time to stop bleeding and effective rate of both groups were observed. Results The time to stop bleeding of treatment group [（29.61_＋6.13） h] was significantly less than that of control group [（44.21_＋9.88） hi, there was signifi- cant difference between two groups （P 〈 0.05）. The total effective rate of treatment group and control group was re- spectively 95.0% and 80.0%, the former was significantly higher than the latter, there was significant difference be- tween two groups （P 〈 0.05）. Conclusion For upper gastrointestinal bleeding, thrombin plus omeprazole has good ef- fect of stopping bleeding, has fewer reverse effect, and worthy of widely application.