正交试验法优选生姜抗晕凝胶膏剂的制备工艺

Optimization of Preparation Process for Ginger Antihalation Gel Ointments by Orthogonal Test

目的:优选生姜抗晕凝胶膏剂的配方工艺。方法:以初黏力、持黏力及综合感官得分为指标进行综合考察,采用正交设计法考察聚丙烯酸钠(PAC-Na),聚乙烯吡咯烷酮(PVP-K90),甘油及甘羟铝用量对凝胶膏剂的配方工艺的影响,确定最佳基质配方。结果:凝胶膏剂基质的最佳配比为PAC-Na-PVP-K90-甘油-甘羟铝8∶3∶45∶1。结论:制备的凝胶膏剂外观平整,黏附性、保湿性符合要求,与生姜抗晕活性成分具有良好的相容性。

Objective： To optimize preparation process of ginger antihalation gel ointments. Method： With initial adhesive force, cohesive forces and appearance score as comprehensive evaluation index, orthogonal test was used to optimize formulation technology of ginger antihalation gel ointments with the amount of PAC-Na, PVP-k90, glycerin, aluminium glycinate as factors. Result： Optimum formulation was as following： PAC-Na- PVP-k90-glycerin-aluminium glycinate 8：3：45： 1. Conclusion： These prepared gel ointments had a smooth appearance, moderate viscosity, good moisture retention and good compatibility with antihalo active ingredients in ginger.