慢性不可预知性应激对大鼠体重、摄食量和行为学的影响研究

The influence research on the weight,ingestion and ethological expressions of chronic unpredictable stress induced depression model rats

目的:研究慢性不可预知性应激对大鼠体重、摄食量和行为学的影响。方法:将16只雄性SD大鼠随机分为正常组、模型组,以孤养加慢性不可预见性应激(CUS)方法复制大鼠抑郁症模型。采用Open-Field法、1%蔗糖水消耗实验及体重变化观察抑郁模型大鼠的行为学变化。结果:与正常组相比,模型组大鼠糖水消耗量明显减低,水平得分、垂直得分、修饰次数和大便颗粒数均明显下降,且体重增长缓慢,有显著性差异(P<0.05)。结论:CUS使大鼠自发活动下降,抑郁对大鼠行为有一定的影响。

Objective：To observe the effect of the weight,ingestion and ethological expressions of chronic unpredictable stress induced depression model rats.Methods：sixteen male SD rats were devided into two groups： normal control and depression model,rat models were established by separation and chronic unpredictable mild stress（CUMS）.open-field、1% test sucrose consumption test and weight were used to observe the behavior in model rats.Results： Compared with normal group,the weight,the frequency of crossing and rearing,the Modification,the Shit particle numbers and the consumption of sucrosum water in depressive disorder rats decreased significantly（P〈0.05）.Conclusion：CUS make rats spontaneous activity decreased,depressed effects on rats behaviour.