2011年河北省发热呼吸道症候群的病毒病原学研究

Study on the viral etiology of febrile respiratory syndrome in Hebei in 2011

目的建立和完善河北省呼吸道传染病病原监测平台,了解河北省发热呼吸道症候群的病毒病原谱构成情况,为临床诊断、治疗和预防策略提供依据。方法选择1家儿童医院和1家综合医院作为监测哨点医院,采集发热呼吸道感染病例的咽拭子标本,采用多重RT-PCR方法检测15种发热呼吸道症候群相关病毒,并进行统计分析。结果187例发热呼吸道感染病例中相关病毒检测阳性75例(40.11%),其中鼻病毒(HRV)、呼吸道合胞病毒A(RSV-A)感染各13例(6.95%)、腺病毒(ADV)感染12例(6.42%),居病毒感染的前3位。病毒混合感染13例(6.95%),以HRV合并其他病毒感染多见。0～岁组感染率最高,10～12月份为感染高峰季节。结论 2011年河北省发热呼吸道症候群感染以HRV、RSV-A和ADV为主,多重感染常见。

Objective To construct and perfect a platform to monitor pathogens responsible for respiratory infections and determine the pathogenic spectrum of febrile respiratory syndrome in Hebei in order to provide data for strategies of clinical diagnosis, treatment, and prevention. Methods A children＇s hospitals and a general hospital were selected as sentinel hospitals. Throat swab specimens were collected from patients with a respiratory tract infection. Fifteen viral pathogens were detected by muhiplex RT PCR. The prevalence and incidence of respiratory viruses was characterized. Results Viruses associated with febrile respiratory syndrome were detected in 187 patients （40.11%）. Among these patients, HRV was detected in 13 （6.95%）, RSV-A was detected in13 （6.95%）, and ADV was detected in12 （6.42%）, accounting for the three most prevalent pathogens. An overlapping viral infection was found in 13 cases; the most frequent combined infection was HRV with another virus. The infection rate was highest among young children 0-1 year of age. The peak season for infection was October to December. Conclusion Febrile respiratory syndrome in Hebei was mostly caused by HRV, RSV-A, and ADV infections in 2011. Combined infections caused by multiple viruses were com mort.