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L-PGDS与中枢神经系统疾病 被引量：2

L-PGDS and central nervous system diseases
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摘要 Lipocalin型前列腺素D合成酶(L-PGDS)是一种双功能蛋白质,具有催化PGD2合成和转运亲脂性物质的作用。L-PGDS在多种中枢神经系统疾病中表达增高,可能与中枢神经细胞凋亡相关、并发挥胶质细胞毒性和神经毒性分子的"清道夫"效应。本文就L-PGDS性质、代谢通路、在中枢神经系统疾病表达及效应等进行综述。 Lipocalin-type prostaglandin D synthase （L-PGDS）, a dual functional protein, acts as a PGD2-producing en zyme and also as a lipophilic ligand-binding protein. The level of L-PGDS expression is enhanced in various central nerv ous system （CNS） diseases. L-PGDS is related to apoptosis and acts as a scavenger of gliotoxic and neurotoxic molecules This article reviews the properties and pathways of L-PGDS in the CNS and the effects of its expression in CNS diseases
作者 陈小华 谷俊朝
机构地区 首都医科大学附属北京友谊医院
出处 《中国病原生物学杂志》 CSCD 北大核心 2013年第3期278-280,共3页 Journal of Pathogen Biology
基金 国家自然科学基金青年科学基金项目(No.81101269) 热带病防治研究北京市重点实验室(NO:BZ0086)首都医科大学省部级重点实验室开放研究课题基金资助项目
关键词 Lipocalin型前列腺素D合成酶 中枢神经系统疾病 凋亡 清道夫 综述 Lipocalin-type prostaglandin D synthasel central nervous system disease~ apoptosis scavenger~ review
分类号 Q559 [生物学—生物化学]
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二级参考文献16

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共引文献22

同被引文献55

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中国病原生物学杂志
2013年 第3期

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