地西他滨联合CAG治疗老年急性髓系白血病的疗效观察

Curative effect of decitabine combined with CAG regimen in older patients with acute myeloid leukemia

目的观察地西他滨联合CAG方案治疗老年急性髓系白血病的疗效和安全性。方法 7例老年急性髓系白血病患者应用地西他滨+CAG方案[地西他滨15 mg/(m2.d),qd,iv,d1-5;阿克拉霉素10 mg/d,qd,iv,d3-6;阿糖胞苷10 mg/m2,q12h,ih,d3-9;G-CSF 300μg,qd,ih d0-9]。观察患者疗效及不良反应。结果 2例使用4个疗程,2例使用3个疗程,1例使用2个疗程,2例使用1个疗程,其中2例获完全缓解,4例获部分缓解,1例疾病进展,最后因肺部感染死亡。结论地西他滨联合CAG方案治疗老年急性髓系白血病,效果良好,安全性高,不良反应少,化疗相关死亡率低。

Objective To investigate the curative effect and safety of decitabine combined with CAG regimen treatment for elderly AML patients. Methods 7 cases of elderly AML patients were treated with decitabine combined with CAG regimen[decitabine 15 mg/（m^2·d）,qd,iv,d1-5,aclarubicin 10 mg/d,qd,iv,d3-6,Ara-c 10 mg/m^2,q12h,ih,d3-9,G-CSF 300 μg,qd,ih,d0-9]. Results 2 cases lasted for 4 courses,and 2 cases for 3 courses,1 case for 2 courses and 2 cases for 1 course.There were 2 cases of CR,4 cases of PR,1 case of NR（died of lung infection）. Conclusion Decitabine combined with CAG regimen is an effective treatment for the elderly AML patients with high safety and low treatment-related mortality.