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1-异丙胺基-3-[2-(2-甲氧乙基)苯氧基]-2-丙醇的合成

Synthesis of 1-(Isopropylamino)-3-[2-(2-methoxyethyl)phenoxy]propan-2-ol
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摘要 1-异丙胺基-3-[2-（2-甲氧乙基）苯氧基]-2-丙醇是美托洛尔有关物质E。为了对美托洛尔产品质量进行控制，合成了美托洛尔有关物质E。路线原料易得，操作简单，提纯方便，总收率31．8％。并经。HNMR、MS等确证目标产物的结构。 1 - （isopropylamino） - 3 - [ 2 - （2 - methoxyethyl） phenoxy ] propan - 2 - ol was the related substance E of Metoprolol, which was synthesized to the quality control of Metoprolol. The process had many advantages, such as readily available materials, convenient operation and simple purification. The total yield of the product was 31.8%. The structure of the product was confirmed by 1H NMR and MS.
作者 陈欢生 陈宇 袁利
机构地区 上海奥博生物医药技术有限公司
出处 《广州化工》 CAS 2013年第6期65-66,97,共3页 GuangZhou Chemical Industry
关键词 美托洛尔 有关物质 合成 Metoprolol related substance synthesis
分类号 O622.6 [理学—有机化学]
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参考文献5

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广州化工
2013年 第6期

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