糖化血红蛋白胱抑素C及视黄醇结合蛋白在糖尿病肾病早期诊断中的表达

Expression of glycated hemoglobin,serum cystatin C and retinol-binding protein in early diagnosis of diabetic nephropathy

目的探讨血清胱抑素C(Cys C)、视黄醇结合蛋白(RBP)及糖化血红蛋白(HbA1c)联合检测对糖尿病肾病早期诊断的诊断价值。方法同时检测106例单纯糖尿病患者(DM组)、95例糖尿病肾病患者(DN组)和108例健康者(健康对照组)血清Cys C、RBP及HbA1c,按照HbA1c的含量分成高、中、低组,并进行相关统计学分析。结果 DM组HbA1c(高值为10.80%±1.80%)与健康对照组(4.70%±0.98%)比较,差异有统计学意义(P<0.01),Cys C、RBP差异无统计学意义(P>0.05);DN组HbA1c高值组HbA1c12.8%±1.8%、Cys C(1.52±0.28)mg/L、RBP(180.4±81)mg/L与健康对照组HbA1c4.70%±0.98%、Cys C(0.58±0.15)mg/L、RBP(42.30±8.63)mg/L比较,差异均有统计学意义(P<0.01)。结论 HbA1c、RBP及Cys C在糖尿病肾病早期诊断中的表达是非常敏感和特异的。

Objective To investigate the diagnostic value of combined detection of serum cystatin C （Cys C）, retinol-binding protein （RBP） and glycosylated hemoglobin in diagnosis of diabetic nephropathy. Methods The ser- um cystatin C （Cys C） ,retinol-binding protein （RBP） and glycosylated hemoglobin （HbAlc） were detected in 106 diabetes （DM） patients （DM group）,95 patients with diabetic nephropathy （DN） and 108 healthy people （control group）. They were divided into high,middle,and low groups in accordance with the glycated hemoglobin （HbAlc） content,and statistical analysis was done. Results The levels of serum Cys C and RBP of patients with diabetic ne- phropathy were significantly higher than those of pure diabetic group and the control group,and the difference was statistically significant （P〈O. 01）. Conclusion The combined detection of Cys C,RBP,and HbAlc for early diagno- sis of diabetic nephropathy has important diagnostic value.