血浆B型脑钠肽与射血分数在扩张型心肌病患者中的应用

Application of plasma B-type natriuretic peptide and ejection fraction on dilated cardiomyopathy patients

目的探讨血浆B型脑钠肽(BNP)与左心室射血分数(LVEF)在扩张型心肌病(DCM)患者中的相关性及其应用。方法选取福建省省立医院2010年1月至2012年7月住院扩张型心肌病患者54例作为DCM组,根据有无并发心力衰竭又分为A组(心力衰竭组,29例),B组(无心力衰竭组,25例),对照组为福建省省立医院非扩张型心肌病患者共36例,测定所有患者血浆中BNP浓度及LVEF值,并观察其ROC曲线特征。结果 DCM组BNP、LVEF值为(3 820.71±2 934.3)ng/L、40.25%±9.80%;对照组BNP、LVEF值为(439.57±597.57)ng/L、58.79%±6.79%,两组之间比较差异均具有统计学意义(P<0.05)。A组患者BNP浓度高于B组患者BNP值,LVEF值低于B组患者,差异具有统计学意义(P<0.05)。DCM组BNP和LVEF之间存在明显的负相关(r=-0.669)。DCM组BNP和LVEF的ROC曲线下面积(AUC)分别是0.898、0.935。结论检测血浆BNP浓度与LVEF对扩张型心肌病尤其是合并有心力衰竭的患者具有重要的临床价值。

Objective To explore the correlation and application of plasma B-type natriuretic peptide （BNP） and left ventricular ejection fraction （LVEF） in dilated cardiomyopathy （DCM） patients. Methods 54 patients with dilated cardiomyopathy were selected as DCM group. Then according to the presence of concurrent heart {ailure,DCM group were divided into group A （heart failure group,29 cases） and group B （without heart failure group,25 cases）. The control group included 36 patients without dilated cardiomyopathy. B-type natriuretic peptide and left ventricular ejection fraction in all patients were detected,and the feature of ROC curves was observed. Results BNP,LVEF lev- els of dilated cardiomyopathy patients were （3 820.71±2 934.31） ng/L,and 40.25%=1=9.80% ,and these of control group were （439.57±597.57）ng/L,and 58.79%±6. 793%,respectively. There was significant difference between the two groups （P〈0.05）. The level of BNP in A group was higher than that in B group,and the level of LVEF in A group was lower than that in B group （P〈0.05）. The plasma BNP level correlated well with LVEF in DCM group （r=-0. 669）. The area under ROC curves of BNP and LVEF were 0. 898 and 0. 935,respectively. Conclusion De- tection of plasma BNP concentration and LVEF on dilated cardiomyopathy especially complicated with heart failure patients have important clinical value.